Ulcerative colitis
Description
An in-depth report on the causes, diagnosis, treatment, and prevention of ulcerative colitis.
Alternative Names
Inflammatory bowel disease; Colitis - ulcerative
Symptoms
The two major inflammatory bowel diseases (IBDs), ulcerative colitis and Crohn's disease, share certain characteristics:
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Symptoms usually appear in young adults.
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Symptoms can develop gradually or have a sudden onset.
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Both are chronic. In either disease, symptoms may flare up (relapse) after symptom-free periods (remission) or symptoms may be continuous without treatment.
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Symptoms can be mild or very severe and disabling.
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The severity of symptoms and relapse rates of both IBDs vary with seasons, with the highest risk in the winter and autumn and lowest in summer.
The two disorders, however, have different symptom profiles. It is important to differentiate between them, since they require different treatments.
Symptoms of Inflammatory Bowel Disease
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Symptoms
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Ulcerative Colitis (UC)
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Crohn's Disease (CD)
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Diarrhea
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Recurrent diarrhea is very common, but onset may be very gradual and mild or it may not be present. Feces may also contain mucus.
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Recurrent diarrhea is fairly common.
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Rectal bleeding
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Blood is almost always present in stools. It may be readily visible or visible using only a microscope (called occult blood).
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Bleeding not as common as in UC, but can occur.
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Constipation
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Constipation can be a symptom of UC, but not as common as diarrhea. Can occur during flare-ups. May occur when the inflamed rectum triggers a reflex response in the colon that causes it to retain the stool.
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Constipation in Crohn's disease is usually a symptom of obstruction in the small intestine.
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Abdominal symptoms
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Pain is not prominent symptom, but can vary. May cause vague discomfort in the lower abdomen, an ache around the top of the hipbone, or cramps in the middle of the abdomen. Severe pain can occur during flare-ups. Vomiting and nausea.
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Hallmark symptom is recurrent episodes of pain in the lower right part of the abdomen or above the pubic bone. Often preceded by and relieved by defecation. Bloating, nausea, and vomiting may also occur. Intestinal pain may also be an indication of a serious condition, such as an abscess, or a perforation of the intestinal wall.
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Fever
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May occur with severe attacks.
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Usually low-grade. Spiking fever and chills indicates complications.
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Loss of appetite, weight loss, and impaired growth in children
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Often not evident in mild or even moderately severe UC. Occasionally impairs growth in children and teenagers.
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Common. Typical weight loss is 10 -20% of normal. Commonly impairs growth in children and teenagers.
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Abnormal defecation:
Increased frequency, a feeling of incomplete evacuation, and tenesmus (a painful urge for a bowel movement even if the rectum is empty). Fecal incontinence.
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Symptoms may be mild or severe.
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Can occur in active stages.
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Anal ulcers and fistulas:
(channels that can burrow between organs, loops of the intestine, or between the intestines and skin).
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Almost never a symptom.
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Fistulas and ulcers around the anus may be early symptoms of CD.
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Neurologic or psychiatric symptoms
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No.
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May be early signs of Crohn's disease when accompanied by gastrointestinal problems.
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Note: A 2001 study reporting that early symptoms (called a prodrome) may appear in Crohn's disease, starting about 7 years before the full-blown symptoms occur. The prodrome symptoms included bloating, diarrhea, stomach pain, fever, weight loss, and fatigue. The prodromal period in ulcerative colitis is much shorter (about a year).
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Review Date: 8/23/2006
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Reviewed By: Harvey Simon, M.D., Editor-in-Chief, Associate Professor of Medicine, Harvard Medical School; Physician, Massachusetts General Hospital
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