Definition of Malaise:

Malaise is a generalized feeling of discomfort, illness, or lack of well-being. It can be associated with a disease. Malaise can be accompanied by a feeling of exhaustion, or of not having enough energy to accomplish usual activities.

Considerations:

Malaise is a nonspecific symptom that can occur with almost any significant infectious, metabolic (endocrine), or systemic (throughout the body) disorder. The onset may be slow or rapid depending on the nature of the disease.

Fatigue accompanies malaise in many common diseases.

Common Causes:

The following lists give examples of the diseases and conditions that can cause malaise.

ACUTE INFECTIOUS DISEASE

• Acute bronchitis or pneumonia
• Acute viral syndrome
• Infectious mononucleosis (EBV)
• Influenza
• Lyme disease

CHRONIC INFECTIOUS DISEASE

• AIDS
• Chronic active hepatitis
• Parasitic disease
• Tuberculosis

CARDIOPULMONARY DISEASE

• Congestive heart failure
• COPD

ORGAN FAILURE

• Acute or chronic kidney disease
• Acute or chronic liver disease

CONNECTIVE TISSUE DISEASE

• Rheumatoid arthritis
• Sarcoidosis
• Systemic lupus erythematosus

ENDOCRINE or METABOLIC

• Adrenal gland dysfunction
• Diabetes
• Pituitary gland dysfunction (rare)
• Thyroid disease

NEOPLASTIC

• Leukemia
• Lymphoma (cancer that starts in the lymph system)
• Solid tumor malignancies, such as colon cancer

BLOOD DISORDERS

• Severe anemia

PSYCHIATRIC

• Depression
• Dysthymia (a long-lasting depressed mood, less severe than depression)

MEDICATIONS

• Anticonvulsant (antiseizure) medications
• Antihistamines
• Beta blockers (medications used to treat heart disease or high blood pressure)
• Psychiatric medications
• Treatments involving several medications