Definition of Necrotizing soft tissue infection:

Necrotizing soft tissue infection is a rare but very severe type of bacterial infection that can destroy the muscles, skin, and underlying tissue. Necrotizing refers to something that causes tissue death.

Causes, incidence, and risk factors:

Many different types of bacteria can cause this type of infection. A very severe and usually deadly form of necrotizing soft tissue infection is due to Streptococcus pyogenes, which is sometimes called "flesh-eating bacteria."

Necrotizing soft tissue infection develops when the bacteria enters the body, usually through a minor cut or scrape. The bacteria begins to grow and release harmful substances (toxins) that:

• Directly kill tissue
• Interfere with the blood flow to the tissue
• Break down materials in the tissue, which rapidly spreads the bacteria, leading to widespread effects such as shock