Definition of Cancer - penis:

Cancer of the penis is cancer that starts in the penis, an organ that makes up part of the male reproductive system.

Causes, incidence, and risk factors:

The exact cause is unknown.

Smegma, a cheese-like, foul-smelling substance found under the foreskin of the penis may increase the risk of penis cancer.

Uncircumcised men who do not keep the area under the foreskin clean and men with a history of genital warts or human papillomavirus (HPV) are at higher risk for this rare disorder.