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Secondary amenorrhea - Overview

Alternative Names

Amenorrhea - secondary

Definition of Secondary amenorrhea:

Secondary amenorrhea is lack of periods for 6 or more months in a woman who has already started menstruation and who is not pregnant, lactating, or in menopause.

See also:

Menstruation - Absent

Primary amenorrhea

Causes, incidence, and risk factors:

About 4% of women have secondary amenorrhea. There are many reasons for missing a period.

You are at an increased risk of secondary amenorrhea if you engage in extreme and prolonged exercise (particularly without adequate conditioning), have less than 15 - 17% body fat, are obese, or take hormonal supplements.

Anxiety and emotional distress can also cause a missed period.

The following drugs may also cause missed periods: 

  • Busulfan
  • Chlorambucil
  • Cyclophosphamide
  • Phenothiazines 
  • Oral contraceptives
  • Non-oral contraceptives such as Depo-Provera

Also, procedures such as a dilation and curettage (D and C) can cause a woman to develop amenorrhea if scar tissue develops within the uterine cavity.

  • Reviewed last on: 5/10/2006
  • Melanie N. Smith, M.D., Ph.D., Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA. Review provided by VeriMed Healthcare Network.

References

Stenchever MA, Droegemueller W, Herbst AR. Comprehensive Gynecology. 4th ed. St. Louis, Mo: Mosby; 2001:1109-1119.

Rakel P, ed. Conn’s Current Therapy 2005. 57th ed. Philadelphia, Pa: WB Saunders; 2005:1291-1293.

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