Definition of Folate-deficiency anemia:

Folate-deficiency anemia is a decrease in red blood cells (anemia) caused by folate deficiency.

Causes, incidence, and risk factors:

Folate, also called folic acid, is necessary for red blood cell formation and growth. You can get folate by eating from green leafy vegetables and liver. Some medications, such as phenytoin (Dilantin), interfere with the absorption of this vitamin. Because folate is not stored in the body in large amounts, a continual dietary supply of this vitamin is needed.

In folate-deficiency anemia, the red cells are abnormally large and are called megalocytes, or megaloblasts in the bone marrow. Subsequently, this anemia may be referred to as megaloblastic anemia

Causes of this anemia are poor dietary intake of folic acid, malabsorption diseases such as celiac disease (sprue), and certain medications. A relative deficiency due to increased need for folic acid may occur in the third trimester of pregnancy.

Risk factors include poor diet (seen frequently in the poor, the elderly, and in people who do not eat fresh fruits or vegetables), eating overcooked food, alcoholism (which interferes with the absorption of folate), history of malabsorption diseases, and pregnancy. The disease occurs in about 4 out of 100,000 people.