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Factor XII (Hageman factor) deficiency - Overview

Definition of Factor XII (Hageman factor) deficiency:

Factor XII deficiency is an inherited disorder with no symptoms. Factor XII is a protein involved in blood clotting. A deficiency of this factor does not cause abnormal bleeding in the affected person, but the blood takes longer than normal to clot in a test tube.

Causes, incidence, and risk factors:

Factor XII deficiency is a rare hereditary disorder. It is usually found when clotting tests are done for routine screening. It is not associated with abnormal bleeding.

  • Reviewed last on: 2/26/2007
  • William Matsui, MD, Assistant Professor of Oncology, Division of Hematologic Malignancies, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD. Review provided by VeriMed Healthcare Network.

References

McPherson RA and Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. Philadelphia, Pa.: WB Saunders; 2006.

Hoffman R, Benz Jr. EJ, Shattil SJ, et al., eds. Hematology: Basic Principles and Practice. 4th ed. Philladelphia, Pa: Churchill Livingston; 2005:2089-90.
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