Definition of Testicular failure:

Testicular failure is the inability of the testicles to produce sperm or male hormones.

See also:

• Hypogonadism
• Secondary hypogonadism

Causes, incidence, and risk factors:

Testicular failure is uncommon. Causes include:

• Certain drugs, including glucocorticoids, ketoconazole, and opioids
• Chromosome problems
• Diseases that affect the testicle, including mumps, orchitis, and testicular cancer
• Injury to the testicles
• Testicular torsion

The following things increase the risk for testicular failure:

• Activities that may cause constant, low-level injury to the scrotum, such as riding a motorcycle
• Frequent and heavy use of marijuana
• Undescended testicles at birth