The hepatitis B virus spreads through blood and other body fluids. Infection can occur if you have:
Blood transfusions
Contact with blood in health care settings
Received a tattoo or acupuncture with contaminated instruments
Shared needles during drug use
Unsafe sex with an infected person
The hepatitis B virus can be passed to an infant during childbirth or shortly thereafter if the mother is infected.
The risk of becoming chronically infected depends on your age at the time of infection. Most newborns and about 50% of children infected with hepatitis B develop chronic hepatitis. Only a few adults infected with HBV develop the chronic condition.
Most of the damage from the hepatitis B virus is due to the body's response to the infection. When the body's immune system detects the infection, it sends out special cells to fight it off. However, these disease-fighting cells can lead to liver inflammation. The liver damage also interferes with the body's ability to get rid of bilirubin, a breakdown product of old red blood cells. This leads to jaundice (yellow discoloration of the eyes and body) and dark urine.
Christian Stone, M.D., Division of Gastroenterology, Washington University in St. Louis School of Medicine, St. Louis, MO. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
References
Lin KW. Hepatitis B. Am Fam Physician. 2004;69(1):75-82.
Goldman L, Ausiello D. Cecil Textbook of Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007.