Pegademase bovine (Injection)

Introduction:

Pegademase Bovine (peg-AD-e-mase BOE-vine)

Replaces enzymes in adenosine deaminase (ADA) deficiency.

Brand Name(s):

Adagen

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You or your child should not use this medicine if you or your child has had an allergic reaction to pegademase bovine or to any product made from a cow. Do not use this medicine if you or your child has certain bleeding disorders (such as severe thrombocytopenia).

How to Use This Medicine:

Injectable

  • Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into one of your muscles.
  • A nurse or other trained health professional will give you this medicine.
  • You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.
  • Use a new needle and syringe each time you inject your medicine.

If a dose is missed:

  • Call your doctor or pharmacist for instructions.

How to Store and Dispose of This Medicine:

  • If you store this medicine at home, keep it in the refrigerator. Do not freeze.
  • Keep all medicine away from children and never share your medicine with anyone.
  • Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine, containers, and other supplies. You will also need to throw away old medicine after the expiration date has passed.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using medicine to treat virus infection (such as vidarabine, Vira-A®).

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or you or your child has bleeding problems or had a bone marrow transplant.
  • Avoid people who are sick or have infections.
  • Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Fever, chills, sore throat, and body aches.
  • Pain, warmth, or burning in fingers, toes, and legs.
  • Shortness of breath, tiredness, or uneven heartbeat.
  • Unusual bleeding, bruising, or weakness.
  • Yellowing of your skin or the whites of your eyes.

If you notice these less serious side effects, talk with your doctor:

  • Headache.
  • Redness, pain, itching, burning, swelling, or a lump under your skin where the shot is given.
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