Lubiprostone (By mouth)

Introduction:

Lubiprostone (loo-bi-PROST-one)

Treats certain types of long-term constipation by helping you have a bowel movement. Also treats irritable bowel syndrome (IBS) in women who have constipation as the main symptom.

Brand Name(s):

Amitiza

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to lubiprostone, or if you have a history of blockage in your stomach or intestines.

How to Use This Medicine:

Capsule, Liquid Filled Capsule

  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
  • It is best to take this medicine with food or milk.
  • Swallow the capsule whole. Do not crush, break, or chew it.
  • Take each dose with at least 8 ounces (1 cup) of water. Drink at least 6 to 8 full glasses of liquid every day to help soften your stools (bowel movements).

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine:

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have stomach pain, nausea, vomiting, severe diarrhea, or a sudden change in bowel habits.
  • Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
  • Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments.
  • If your symptoms do not improve or if they get worse, call your doctor.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Chest pain or shortness of breath.
  • Nausea, vomiting, severe diarrhea, loose or watery stools, or stomach pain or swelling.
  • Swelling in your hands, ankles, and feet.

If you notice these less serious side effects, talk with your doctor:

  • Dizziness or headache.
  • Dry mouth.
  • Passing gas or upset stomach.
  • Tiredness.
  • Warmth or redness in your face, neck, arms, or upper chest.
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