Bivalirudin (Injection)

Introduction:

Bivalirudin (bye-VAL-i-roo-din)

Prevents blood clots during a heart procedure called angioplasty. This medicine is used with aspirin.

Brand Name(s):

Angiomax

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not receive this medicine if you have had an allergic reaction to bivalirudin, or if you have any active bleeding.

How to Use This Medicine:

Injectable

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins.
  • A nurse or other trained health professional will give you this medicine.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using blood thinners such as heparin or warfarin (Coumadin®), or medicines to dissolve blood clots such as streptokinase (Streptase®), urokinase (Abbokinase®), alteplase (Activase®), or reteplase (Retavase®).

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have a kidney problem, bleeding disorder such as hemophilia, or if you bruise easily. Tell your doctor if you are receiving brachytherapy (a radiation treatment).
  • You may bleed and bruise more easily while you are using this medicine. Be extra careful to avoid injuries until the effects of the medicine have worn off. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers. Avoid picking your nose. If you need to blow your nose, blow it gently.
  • Watch for any bleeding from open areas such as around the injection site. Also check for blood in your urine or stool. If you have any bleeding or injuries, tell your doctor right away.
  • Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Bloody or black, tarry stools.
  • Chest pain.
  • Decrease in how much or how often you urinate.
  • Fever.
  • Lightheadedness or fainting.
  • Numbness or weakness in your arm or leg, or on one side of your body.
  • Pain, itching, burning, swelling, bleeding, or a lump under your skin where the needle is placed.
  • Red or dark brown urine.
  • Slow heartbeat.
  • Sudden or severe headache, problems with vision, speech, or walking.
  • Unusual bleeding, bruising, or weakness.

If you notice these less serious side effects, talk with your doctor:

  • Back or hip pain.
  • Mild headache.
  • Nausea, vomiting, stomach pain, or upset stomach.
  • Trouble sleeping, anxiety, or nervousness.
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