Alglucosidase alfa (Injection)

Introduction:

Alglucosidase Alfa (al-gloo-KOE-si-dase AL-fa)

Treats Pompe disease (deficiency in the enzyme acid alpha-glucosidase).

Brand Name(s):

Myozyme

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

You should not use this medicine if you have had an allergic reaction to alglucosidase alfa.

How to Use This Medicine:

Injectable

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins.
  • A nurse or other trained health professional will give you this medicine.
  • Your doctor may have your name placed on a patient registry list. Ask your doctor if you have any questions.

If a dose is missed:

  • Call your doctor or pharmacist for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have recently been sick.
  • A small number of people who have used this medicine developed serious allergic reactions. Most of the cases include heart, lung, and/or skin problems. Serious heart problems have also occurred in patients while receiving general anesthesia for catheter placement prior to receiving this medicine.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Chest pain, trouble breathing.
  • Ear pain or discharge, trouble hearing.
  • Fast or slow heartbeat.
  • Fever, chills, runny nose, cough, sore throat, and body aches.
  • Lightheadedness or fainting.
  • Shortness of breath, cold sweat, and bluish-colored skin.
  • Swelling on the face or around your eyes.
  • Tremors.
  • Unusual bleeding, bruising, or weakness.

If you notice these less serious side effects, talk with your doctor:

  • Agitation, irritability, restlessness.
  • Headache.
  • Increased sweating or tearing.
  • Nausea, vomiting, diarrhea, constipation, upset stomach, or stomach pain.
  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed.
  • Pale skin, or skin rash or itchiness.
  • Sores or white patches on your lips, mouth, tongue, or throat.
  • Warmth or redness in your face, neck, arms, or upper chest.
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