Amobarbital and Secobarbital
Pronunciation
(am oh BAR bi tal & see koe BAR bi tal)
U.S. Brand Names
Tuinal® [DSC]
Synonyms
Secobarbital and Amobarbital
Generic Available
No
Use
Short-term treatment of insomnia
Restrictions
C-II
Pregnancy Risk Factor
D
Lactation
Excretion in breast milk unknown/not recommended
Contraindications
Hypersensitivity to secobarbital, amobarbital, or any component of the formulation; CNS depression; marked liver impairment; latent porphyria; pregnancy
Warnings/Precautions
Safety has not been established in children <6 years of age; potential for drug dependency exists; avoid alcoholic beverages; use with caution in patients with CHF, hepatic or renal impairment, hypovolemic shock
Adverse Reactions
>10%:
Central nervous system: Dizziness, lightheadedness, drowsiness, "hangover" effect
Local: Pain at injection site
1% to 10%:
Central nervous system: Confusion, mental depression, unusual excitement, nervousness, faint feeling, headache, insomnia, nightmares
Gastrointestinal: Constipation, nausea, vomiting
<1%: Agranulocytosis, dermatitis, exfoliative, hallucinations, hypotension, megaloblastic anemia, respiratory depression, skin rash, Stevens-Johnson syndrome, thrombocytopenia, thrombophlebitis
Drug Interactions
Amobarbital:
Induces
CYP2A6 (strong)
Secobarbital:
Induces
CYP2A6 (strong), 2C8/9 (strong)
Also see individual agents.
Pharmacodynamics/Kinetics
See individual agents.
Dosage
Adults: Oral: 1-2 capsules at bedtime
Patient Education
See individual agents.
Pregnancy/breast-feeding precautions:
Inform prescriber if you are or intend to become pregnant. Breast-feeding is not recommended.
Dental Health: Effects on Dental Treatment
No significant effects or complications reported
Dental Health: Vasoconstrictor/Local Anesthetic Precautions
No information available to require special precautions
Dosage Forms
Capsule: Amobarbital 50 mg and secobarbital 50 mg
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