Acetaminophen

Pronunciation

U.S. Brand Names

Acephen® [OTC]; Aspirin Free Anacin® Maximum Strength [OTC]; Cetafen® [OTC]; Cetafen Extra® [OTC]; Comtrex® Sore Throat Maximum Strength [OTC]; ElixSure™ Fever/Pain [OTC]; FeverALL® [OTC]; Genapap® [OTC]; Genapap® Children [OTC]; Genapap® Extra Strength [OTC]; Genapap® Infant [OTC]; Genebs® [OTC]; Genebs® Extra Strength [OTC]; Mapap® [OTC]; Mapap® Arthritis [OTC]; Mapap® Children's [OTC]; Mapap® Extra Strength [OTC]; Mapap® Infants [OTC]; Redutemp® [OTC]; Silapap® Children's [OTC]; Silapap® Infants [OTC]; Tylenol® [OTC]; Tylenol® 8 Hour [OTC]; Tylenol® Arthritis Pain [OTC]; Tylenol® Children's [OTC]; Tylenol® Extra Strength [OTC]; Tylenol® Infants [OTC]; Tylenol® Junior Strength [OTC]; Tylenol® Sore Throat [OTC]; Valorin [OTC]; Valorin Extra [OTC]

Synonyms

APAP; N-Acetyl-P-Aminophenol; Paracetamol

Generic Available

Yes

Canadian Brand Names

Abenol®; Apo-Acetaminophen®; Atasol®; Pediatrix; Tempra®; Tylenol®

Use

Treatment of mild to moderate pain and fever (antipyretic/analgesic); does not have antirheumatic or anti-inflammatory effects

Use - Dental

Treatment of postoperative pain

Pregnancy Risk Factor

Lactation

Enters breast milk/compatible

Contraindications

Hypersensitivity to acetaminophen or any component of the formulation

Warnings/Precautions

Limit dose to <4 g/day. May cause severe hepatic toxicity on acute overdose; in addition, chronic daily dosing in adults has resulted in liver damage in some patients. Use with caution in patients with alcoholic liver disease; consuming

3 alcoholic drinks/day may increase the risk of liver damage. Use caution in patients with known G6PD deficiency.

OTC labeling: When used for self-medication, patients should be instructed to contact healthcare provider if used for fever lasting >3 days or for pain lasting >10 days in adults or >5 days in children.

Adverse Reactions

Frequency not defined.

Dermatologic: Rash

Endocrine & metabolic: May increase chloride, uric acid, glucose; may decrease sodium, bicarbonate, calcium

Hematologic: Anemia; blood dyscrasias (neutropenia, pancytopenia, leukopenia)

Hepatic: May increase bilirubin, alkaline phosphatase

Renal: May increase ammonia, nephrotoxicity with chronic overdose, analgesic nephropathy

Miscellaneous: Hypersensitivity reactions (rare)

Overdosage/Toxicology

Symptoms of overdose include hepatic necrosis, transient azotemia, renal tubular necrosis with acute toxicity, anemia, and GI disturbances with chronic toxicity. Treatment consists of acetylcysteine 140 mg/kg orally (loading) followed by 70 mg/kg every 4 hours for 17 doses; therapy should be initiated based upon laboratory analysis suggesting a high probability of hepatotoxic potential. Activated charcoal is very effective at binding acetaminophen. Intravenous acetylcysteine should be reserved for patients unable to take oral forms.

Drug Interactions

Substrate (minor) of CYP1A2, 2A6, 2C8/9, 2D6, 2E1, 3A4; Inhibits CYP3A4 (weak)

Decreased effect: Barbiturates, carbamazepine, hydantoins, rifampin, sulfinpyrazone may decrease the analgesic effect of acetaminophen; cholestyramine may decrease acetaminophen absorption (separate dosing by at least 1 hour)

Increased toxicity: Barbiturates, carbamazepine, hydantoins, isoniazid, rifampin, sulfinpyrazone may increase the hepatotoxic potential of acetaminophen; chronic ethanol abuse increases risk for acetaminophen toxicity; effect of warfarin may be enhanced

Ethanol/Nutrition/Herb Interactions

Ethanol: Excessive intake of ethanol may increase the risk of acetaminophen-induced hepatotoxicity. Avoid ethanol or limit to <3 drinks/day.

Food: Rate of absorption may be decreased when given with food.

Herb/Nutraceutical: St John's wort may decrease acetaminophen levels.

Stability

Do not freeze suppositories.

Mechanism of Action

Inhibits the synthesis of prostaglandins in the central nervous system and peripherally blocks pain impulse generation; produces antipyresis from inhibition of hypothalamic heat-regulating center

Pharmacodynamics/Kinetics

Onset of action: <1 hour

Duration: 4-6 hours

Absorption: Incomplete; varies by dosage form

Protein binding: 8% to 43% at toxic doses

Metabolism: At normal therapeutic dosages, hepatic to sulfate and glucuronide metabolites, while a small amount is metabolized by CYP to a highly reactive intermediate (acetylimidoquinone) which is conjugated with glutathione and inactivated; at toxic doses (as little as 4 g daily) glutathione conjugation becomes insufficient to meet the metabolic demand causing an increase in acetylimidoquinone concentration, which may cause hepatic cell necrosis

Half-life elimination: Prolonged following toxic doses

Neonates: 2-5 hours

Adults: 1-3 hours (may be increased in elderly; however, this should not affect dosing)

Time to peak, serum: Oral: 10-60 minutes; may be delayed in acute overdoses

Excretion: Urine (2% to 5% unchanged; 55% as glucuronide metabolites; 30% as sulphate metabolites)

Dosage

Oral, rectal:

Children <12 years: 10-15 mg/kg/dose every 4-6 hours as needed; do not exceed 5 doses (2.6 g) in 24 hours; alternatively, the following age-based doses may be used; see table.

Note:

Acetaminophen Dosing

Age	Dosage (mg)	Age	Dosage (mg)
0-3 mo	40	4-5 y	240
4-11 mo	80	6-8 y	320
1-2 y	120	9-10 y	400
2-3 y	160	11 y	480

Note: Higher rectal doses have been studied for use in preoperative pain control in children. However, specific guidelines are not available and dosing may be product dependent. The safety and efficacy of alternating acetaminophen and ibuprofen dosing has not been established.

Adults: 325-650 mg every 4-6 hours or 1000 mg 3-4 times/day; do not exceed 4 g/day

Dosing interval in renal impairment:

Clcr 10-50 mL/minute: Administer every 6 hours

Clcr<10 mL/minute: Administer every 8 hours (metabolites accumulate)

Hemodialysis: Moderately dialyzable (20% to 50%)

Dosing adjustment/comments in hepatic impairment: Use with caution. Limited, low-dose therapy usually well tolerated in hepatic disease/cirrhosis. However, cases of hepatotoxicity at daily acetaminophen dosages <4 g/day have been reported. Avoid chronic use in hepatic impairment.

Administration

Suppositories: Do not freeze

Suspension, oral: Shake well before pouring a dose

Monitoring Parameters

Relief of pain or fever

Reference Range

Therapeutic concentration (analgesic/antipyretic): 10-30 mcg/mL

Toxic concentration (acute ingestion) with probable hepatotoxicity: >200 mcg/mL at 4 hours or 50 mcg/mL at 12 hours after ingestion

Dietary Considerations

Chewable tablets may contain phenylalanine (amount varies, ranges between 3-12 mg/tablet); consult individual product labeling.

Patient Education

Take exactly as directed; do not increase dose or frequency. Most adverse effects are related to excessive use. Take with food or milk. While using this medication, avoid or limit alcohol to <3 drinks/day and avoid other prescription or OTC medications that contain acetaminophen. Maintain adequate hydration (2-3 L/day of fluids) unless instructed to restrict fluid intake. This medication will not reduce inflammation; consult prescriber for anti-inflammatory, if needed. Report unusual bleeding (stool, mouth, urine) or bruising; unusual fatigue and weakness; change in elimination patterns; or change in color of urine or stool.

Anesthesia and Critical Care Concerns/Other Considerations

Avoid excessive doses of acetaminophen particularly in patients with a significant alcohol history or poor nutritional habits. The 2002 ACCM/SCCM guidelines for analgesia (critically-ill adult) recommend prescribing <2 g/day for patients with a significant alcohol history or those with malnutrition. Other patients may be limited to <4 g/day. Susceptibility to acetaminophen hepatotoxicity may be due to induction of hepatic enzymes caused by chronic alcohol ingestion, depletion of glutathione, malnutrition, and impaired glucuronidation caused by fasting.

Dental Health: Effects on Dental Treatment

No significant effects or complications reported

Mental Health: Effects on Mental Status

None reported

Mental Health: Effects on Psychiatric Treatment

Barbiturates and carbamazepine may increase the hepatotoxic potential of acetaminophen

Dosage Forms

Caplet (Cetafen Extra® Strength, Genapap® Extra Strength, Genebs® Extra Strength, Mapap® Extra Strength, Tylenol® Extra Strength): 500 mg

Caplet, extended release (Mapap® Arthritis, Tylenol® Arthritis Pain): 650 mg

Capsule (Mapap® Extra Strength): 500 mg

Elixir: 160 mg/5 mL (120 mL, 480 mL, 3780 mL)

Mapap® Children's: 160 mg/5 mL (120 mL) [alcohol free; contains benzoic acid and sodium benzoate; cherry flavor]

Gelcap (Mapap® Extra Strength, Tylenol® Extra Strength): 500 mg

Geltab (Mapap® Extra Strength, Tylenol® Extra Strength): 500 mg

Geltab, extended release (Tylenol® 8 Hour): 650 mg

Liquid, oral: 500 mg/15 mL (240 mL)

Comtrex® Sore Throat Maximum Strength: 500 mg/15 mL (240 mL) [contains sodium benzoate; honey lemon flavor]

Genapap® Children: 160 mg/5 mL (120 mL) [contains sodium benzoate; cherry and grape flavors]

Silapap®: 160 mg/5 mL (120 mL, 240 mL, 480 mL) [sugar free; contains sodium benzoate; cherry flavor]

Tylenol® Extra Strength: 500 mg/15 mL (240 mL) [contains sodium benzoate; cherry flavor]

Tylenol® Sore Throat: 500 mg/15 mL (240 mL) [contains sodium benzoate; cherry and honey-lemon flavors]

Solution, oral drops: 80 mg/0.8 mL (15 mL) [droppers are marked at 0.4 mL (40 mg) and at 0.8 mL (80 mg)]

Genapap® Infant: 80 mg/0.8 mL (15 mL) [fruit flavor]

Silapap® Infant's: 80 mg/0.8 mL (15 mL, 30 mL) [contains sodium benzoate; cherry flavor]

Solution, oral: 160 mg/5 mL (120 mL, 480 mL)

Suppository, rectal: 120 mg, 325 mg, 650 mg

Acephen®: 120 mg, 325 mg, 650 mg

FeverALL®: 80 mg, 120 mg, 325 mg, 650 mg

Mapap®: 125 mg, 650 mg

Suspension, oral:

Mapap® Children's: 160 mg/5 mL (120 mL) [contains sodium benzoate; cherry flavor]

Tylenol® Children's: 160 mg/5 mL (120 mL, 240 mL) [contains sodium benzoate; bubble gum, cherry, and grape flavors]

Suspension, oral drops:

Mapap® Infants 80 mg/0.8 mL (15 mL, 30 mL) [contains sodium benzoate; cherry flavor]

Tylenol® Infants: 80 mg/0.8 mL (15 mL, 30 mL) [contains sodium benzoate; cherry and grape flavors]

Syrup, oral (ElixSure™ Fever/Pain): 160 mg/5 mL (120 mL) [bubble gum, cherry, and grape flavors]

Tablet: 325 mg, 500 mg

Aspirin Free Anacin® Extra Strength, Genapap® Extra Strength, Genebs® Extra Strength, Mapap® Extra Strength, Redutemp®, Tylenol® Extra Strength, Valorin Extra: 500 mg

Cetafen®, Genapap®, Genebs®, Mapap®, Tylenol®, Valorin: 325 mg

Tablet, chewable: 80 mg

Genapap® Children: 80 mg [contains phenylalanine 6 mg/tablet; fruit and grape flavors]

Mapap® Children's: 80 mg [contains phenylalanine 3 mg/tablet; bubble gum, fruit, and grape flavors]

Mapap® Junior Strength: 160 mg [contains phenylalanine 12 mg/tablet; grape flavor]

Tylenol® Children's: 80 mg [fruit and grape flavors contain phenylalanine 3 mg/tablet; bubble gum flavor contains phenylalanine 6 mg/tablet]

Tylenol® Junior Strength: 160 mg [contains phenylalanine 6 mg/tablet; fruit and grape flavors]

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International Brand Names

Abenol® (CA); Abrolet® (IL); Abrol® (IL); Acamol® (AR, CL, IL); Acamoli Forte® (IL); Acamoli® (IL); Ace® (BD); Acenol® (PL); Acertol® (ES); Acetafen® (MX); Acetagen® (EC); Acetalgin® (CH); Acetamil® (BR); Acetamin® (EC); Acetaminofen® (CO, EC); Acetaminofen Genfar® (EC); Acetamol® (IT); Aceta-P® (TH); Acetasil® (TH); Acetofen® (BR); Acetolit® (AR); Acet® (SG); Actol® (BD); Actron® (ES); Acu-Paracetamol® (ZA); Adco-Paracetamol® (ZA); Adol® (RO); Adorem® (CO); Afebrin® (HK, ID); Afebryl Mono® (BE, LU); Aldolor® (IL, RO); Algiafin® (CL); Algogen® (TH); Algostase Mono® (BE); Alphagesic® (ID); Alpiny® (JP); Alvedon forte® (SE); Alvedon® (GB, NO, SE); Ambeedol® (BD); A-Mol® (TH); A-Mycin® (BD); Anadin-3® (ZA); Anadin dla dzieci® (PL); Anadin Paracetamol® (IE); Anadin® (PL); Analpyrin® (BD); Anasor® (HN); Andox® (MX); Anhiba® (JP); Antidol® (ES, PL); APA® (AT, BD); Apamide® (DO); APAP® (PL); A-Per® (TR); Apiretal® (ES); Apo-Acetaminophen® (CA, CZ); Apo-Paradex® (NZ); Apracur Granulado® (AR); Arfen® (HK, JO); Asomal® (TR); AT98® (BD); Atasol® (CA); Atopen® (BD); Atralidon® (PT); Avlopol® (BD); Babinoks Pediatrik® (TR); Bandol® (ES); Bebetina® (EC); Becetamol® (CH); ben-u-ron® (AT); Ben-u-ron® (CH); ben-u-ron® (DE, HU); Benuron® (PL); ben-u-ron® (PT); Berko-Setamol® (TR); Biogesic® (ID, SG, TH); Biogrip-T® (AR); Bodrex forte® (ID); Brunomol® (ZA); Calapol® (ID); Calmanticold® (ES); Calorex® (ID); Calpol 6 plus® (BG, GB); Calpol® (BG, BR, CY, CZ, GB, HK, IE, IN, JO, KW, LB, PL, RO, RU, SG, SI, SY, TH, TR, ZA); Captin® (DE); Causalon® (AR); Cefalex® (BR); Cemol® (TH); Cetadol® (BD); Cetafrin® (BR); Cetajap® (BD); Cetalgin® (BD); Cetam® (BD); Children's Chewable non Aspirin® (RO); Children's Panadol® (SG); Children's Tylenol® (AU, ZA); Citodon® (SE); Citripancek® (SI); Citripan® (SI); Claradol® (FR); Codipar® (PL); Contac® (DE); Contra-Schmerz P® (CH); Contratemp® (ID); Cotibin Analgesico-Antipiretico Adultos® (CL); Crocin® (IN); Croix Blanche® (BE, LU); Cupanol® (ES, ID); Curadon forte® (SE); Curadon® (SE); Curpol® (BE, LU); Custodial® (AR); Dafalgan® (BE, CH, CZ, ES, FR, LU, PL, PT); Dafalgan Odis® (BE, CH); Daga® (TH); Daimeton® (CL); Daleparin® (CL); Daleron® (HR, SI); Dapyrin® (ID); Datril® (MX); Debrinol® (ID); Depanas® (ID); Dexamol® (IL); Dexamol Kid® (IL); Dhamol® (HK, SG); Dirox® (AR); Disprin Paracetamol® (IN); Disprol® (GB, IE); Docpara® (BE); Dolex® (CO); Dolgesic® (ES); Doliprane® (FR, IN, PL); Dolitabs® (FR); Dolko® (FR); Dolofen® (CO); Dolol-Instant® (BE); Dolomol® (EG, KW, LB, SY); Doloptal® (CO); Doloreduct® (DE); Dolorol® (ZA); DoloStop® (CH); Dolostop® (ES); Dolotec® (FR); Dolprone® (BE, CH, LU); Dol-Stop® (LU); Dorico® (BR); Dorocoff® (DE); Dristancito® (AR); Dumin® (ID); Duorol® (ES); Dymadon® (AU); Efferalgan® (BE, BG, CZ, ES, FR, HK, HR, HU, IL, IT, LU, PL, PT, RO, SI, TR, YU); Efferalgan jeune enfant® (RO); Efferalgan Nourissons® (RO); Efferalganodis® (FR); Efferalgan Paracetamol® (HU); Efferalgan uz Pediatric® (RO); Efpa Efervesan® (TR); Eftazid® (ES); Ekosetol® (TR); Empaped® (ZA); Emsgrip® (BR); Enelfa® (DE, EG, LU); Eraldor® (EC); Etoran® (PL); Expandox® (FR); Extra Strength non Aspirin® (RO); Farmadol® (ID); Febralgin® (BR); Febrectal® (ES); Febricet® (RO, YU); Febridol® (AU); Fensum® (DE); Fevac® (BD); Fevamol® (ZA); Fevrin® (ID); Fibrexin® (SG); Fiebrolito® (AR); Fitamol® (BD); Gelocatil® (ES); Geluprane® (FR); Genamol® (BD); Geniol-P® (CL); Geralgine-P® (TR); Getol® (BD); G-Paracetamol® (BD); Gripin Bebe® (TR); Grippostad® (AT, BG, DE, HU, PL); Gunaceta® (ID); Hedex® (NL); Hepa® (BD); Herron Paracetamol® (AU); Ildamol® (IL); Inalgex® (HK); Infadrops® (GB); Infant's Tylenol Acetam.® (RO); Infants' Tylenol® (RO, ZA); Influbene N® (CH); Itedal® (AR); Jopamol® (BG); Julphadol® (EC); Junior Disprol® (HK); Kafa® (CH); Kemolas® (ID); Kenox® (CO); Kinderfinimal® (NL); Kitadol® (CL); Kit-Syrup® (TH); Kratofin simplex® (AT); Kyofen® (CO); Labamol® (IL); Lanamol® (ID); Lekadol® (HR, PL, RU, SI); Lemgrip® (BE, LU); Lonarid mono® (BE, LU); Lotemp® (TH); Lupocet® (HR); Magnidol® (MX); Malex® (CH); Medibudget Schmerztabletten Paracetamol® (CH); Medinol® (GB); Medipirin® (RU); Medipyrin® (CZ); Medpramol Syrup® (ZA); Mejoral® (AR); Melabon Infantil® (ES); Merck-Gesic® (ZA); Mexalen® (AT, CZ, HU); Minafen® (TR); Minoset® (TR); Miralgin® (YU); Momentum® (AT, LU, NL); Mono Praecimed® (DE); Nalgesik® (ID); Napa® (BD); Napafen® (EC); Napamol® (ZA); Naprex® (SG); Nasamol® (ID); Navamol® (BD); Neodolito® (MX); Neodol® (MX); Neuridon® (LU); New Cortal for Children® (HK); Nina® (CH); Nodipir® (AR); Nodolex® (AR); No-Febril® (AR); Nomal® (BE); Noral® (TR); Normaflu® (IT); Normotemp® (EC); Novo-Gesic® (PL); N-Paracetamol® (RO); Nufadol® (ID); Osa® (CH); Ottopan® (ID); Pacemol® (BR, SG); Pacet® (IL); Pacimol® (IN, RU, ZA); Paedialgon® (DE); Painamol® (ZA); Paldesic® (GB); Pamol® (DK, ID, LB, NO, RO); Panadol® (AU, BE, BG, CH, CL, CZ, DE, ES, FI, FR, GB, HK, HR, HU, ID, IE, IT, LU, NL, NZ, PL, RO, RU, SG, SI, TH, TR, YU); Panadol Baby® (BG, CZ, HR, SI); Panadol Baby & Infant® (BG, HU, PL, RO); Panadol® for children (SG); Panadol Junior® (BG, NL); Panadol Soluble® (BG, GB, HU, SG); Panado® (ZA); Panamax® (AU); Panam Retard® (DK); Panasorbe® (PT); Panax® (YU); Panodil® (DK, NO, SE); Para® (BD); Paracap® (TH); Para-C® (BD); Paracemol® (PL); Paracen® (BG, KW, LB, MA, MY, SY); Paracenol® (PL); Paracetamol 1A-Pharma® (DE); Paracetamol 500mg-Lennon Tablets® (ZA); Paracetamol AL® (DE); Paracetamol Alpharma ApS® (SG); Paracetamol® (AR, AU, BG, CL, DE, GB, HR, ID, NO, NZ, PL, RO, RU, YU); Paracetamol AZU® (DE); Paracetamol BC® (DE); Paracetamol Berlin-Chemie® (RU); Paracetamol beta® (DE); Paracetamol Denk® (DE); Paracetamol Dexa Medica® (ID); Paracetamol Edigen® (ES); Paracetamol Elixir "S.A.D."® (ZA); Paracetamol Fada® (AR); Paracetamol Fecofar® (AR); Paracetamol Fortbenton® (AR); Paracetamol Gelos® (ES); Paracetamol Geminis® (ES); Paracetamol Genericon® (AT); Paracetamol Hänseler® (CH); Paracetamol Heumann® (DE); Paracetamol Hexal® (DE); Paracetamoli® (SI); Paracetamol Jadran (HR); Paracetamol L.CH.® (CL); Paracetamol Lennon® (ZA); ParaCetaMol Lichtenstein® (DE); Paracetamol-Lünopharm® (DE); Paracetamol Mundogen® (ES); Paracetamolo D&G® (IT); Paracetamolo élan® (CH); Paracetamolo® (IT); Paracetamolo-ratiopharm® (IT); Paracetamolo Teva® (IT); Paracetamolo Unifarm® (IT); Paracetamol Pediyatrik® (TR); Paracetamol Pharmagenus® (ES); Paracetamol Pharmavit® (HU); Paracetamol Raffo® (AR); Paracetamol-ratiopharm® (DE, FI, LU, RU); Paracetamol Rösch® (AT); Paracetamol-saar® (DE); Paracetamol SAD® (DK); Paracetamol Sandoz® (DE); Paracétamol SmithKline Beecham® (FR); Paracetamol Stada® (DE); Paracetamol Tablets® (AU); paracetamol von ct® (DE); Paracetamol Winthrop® (ES); Paracet Junior® (TR); Paracet® (NO, RU, TH, YU); Paracin Kid Tabs.® (IN); Paradco Syrup® (ZA); Paradol® (BD); Parageniol® (AR); Parahexal® (AU); Parakapton® (AT); Paralen® (CZ); Paralgen® (BR); Paralgin® (AU); Paralief® (IE); Paralink® (IE); Paralyoc® (FR); Paramed® (ZA); Paramidol® (RO); Paramolan® (IL, PT); Paramol® (ID, PL, RO, TH); Paramol T.P.® (TH); Paranox-S® (TR); Paranox® (TR); Parapaed® (DE, IE); Paraphar® (BE); Parapyrol® (BD); Parasedol® (TR); Para-Suppo® (FI); Para-Tabs® (FI); Paratabs® (IE); Paratem® (BD); Paratol® (TH); Paratral® (AR); Parat® (TH); Para-z-mol® (AR); Parcetol® (TR); Parmol® (AU); Parol® (TR); Paroma® (TR); Parsel® (PT); Partamol® (TH); PCM-Hemofarm® (YU); PCM-Hemopharm® (DE); Pediapirin® (ES); Pediatrix (CA); Peinfort® (AT); Pemol® (TH); Perdolan® (BE, LU); Perfalgan® (AT, CH, DE, DK, FI, FR, PL, SE); Perfusalgan® (BE); Pe-Tam® (BE, LU); PH4 Plus® (AR); Pharmacard Family Schmerzen & Fieber® (CH); Pharmadol® (TR); Pinex® (DK, NO); Piramin® (BR); Plicet® (HR, PL); Polmofen® (TR); Poro YSP® (SG); Predimol® (IN); Predualito® (AR); Prodenas® (ID); Progesic® (HK, ID); Prolief® (ZA); Propyretic® (ID); Puernol® (IT); Pyrac® (BD); Pyracon® (TH); Pyradol® (ZA); Pyralgin® (BD); Pyretal® (TH); Pyrex® (ID); Pyrexin® (ID); Pyrexon® (IN); Pyridol® (ID); Pyrin® (BD); QAP® (BD); Ramol® (TH); Rapidol® (CL, SG); Reliv® (SE); Remalgin® (BD); Remedol® (CY, JO, SG); Remol® (BD); Resakal® (ES); Rivodol® (CH); Rokamol® (IL); RubieMol® (DE); Rubophen® (HU); Sanador® (RO); Sanicet® (YU); Sanicopyrine® (BE); Sanidol® (BG, RU); Sanmol® (ID); Sara® (TH); Sedalito® (MX); Sedalon® (TR); Seranex N® (CH); Servigesic® (BD, HK); Seskamol® (TR); Setamol® (AU, TR); Sifenol® (TR); Sinapol® (BD); Sinaspril Paracetamol® (NL); Sinedol® (DO, MX); Siniphen neue Formel® (CH); Sinmol® (ES); Sinpro N® (DE); Sumagesic® (ID); Supadol mono® (BE, LU); Supramol® (IL); Supramol-M® (IL); Tabcin Caliente® (AR); Tabcin® (PL); Tachipirina® (IT); Tafirol® (AR); Tamen® (BD); Tamifen® (EC); Tamol® (TR); Tandamol® (BD); Tazamol® (PL); Temfal® (BD); Tempac® (BD); Temperal® (ES, MX); Tempil® (BD); Tempo® (TR); Tempra® (BE, CA, CL, CN, CO, CR, EC, GT, HN, ID, LU, MX, PA, SV, TH); Termacet® (TR); Termagon® (ID); Termalgin® (CH, ES); Termalgine® (TR); Termax® (EC); Termofin® (EC); Termofren® (AR); Termol® (BR); Termo-Ped® (BR); Tiffy® (HK); Tilekin® (BR); Tiptipot Aldolor® (IL); Togal® (DE); Toximer® (AT); Treupel Dolo Paracetamol® (CH); Treupel mono® (DE); Treuphadol® (CH); Tumid® (TH); Turpan® (ID); Tylenex® (BR); Tylenol® (AR, AU, BG, CA, CH, CY, CZ, EG, ES, HK, IE, JO, LB, MT, PT, SY, TH, ZA); Tylenol Extra Strength® (RO); Tylenol Forte® (BG, PL); Tylex® (CR, DO, GT, HN, MX, PA, SV); Tylol Baby Ped.® (TR); Tymol® (TH); Ultrafen® (DO); Ultragin® (IN); Umbral® (EC); Unigrip® (BR); Unimol® (TH); Varipan® (ZA); Vemol® (TH); Vermidon® (TR); Vick Vitapyrena® (AR); Viclor Richet® (AR); Vimoli® (IL); Volpan® (TR); Winadol® (CO, EC); Winasorb® (CL, CR, GT, HN, PA, SV); Winpain® (ZA); Xebramol® (TH); Xepamol® (ID); Zaldaks® (TR); Zaramol® (PT); Zerin® (BD); Zolben® (CH, CL)

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